Assessment of DNA complexation onto polyelectrolyte-coated magnetic silica nanoparticles

Dávila-Ibáñez, Ana B., Buurma, Niklaas Jan ORCID: https://orcid.org/0000-0003-0260-5057 and Salgueiriño, Verónica 2013. Assessment of DNA complexation onto polyelectrolyte-coated magnetic silica nanoparticles. Nanoscale 5 (11) , pp. 4797-4807. 10.1039/c3nr34358h

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Abstract

The polyelectrolyte–DNA complexation method to form magnetoplexes using silica-coated iron oxide magnetic nanoparticles as inorganic substrates is an attractive and promising process in view of the potential applications including magnetofection, DNA extraction and purification, and directed assembly of nanostructures. Herein, we present a systematic physico-chemical study that provides clear evidence of the type of interactions established, reflects the importance of the DNA length, the nanoparticle size and the ionic strength, and permits the identification of the parameters controlling both the stability and the type of magnetoplexes formed. This information can be used to develop targeted systems with properties optimized for the various proposed applications of magnetoplexes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	RSC Publishing
ISSN:	2040-3364
Last Modified:	24 Oct 2022 11:13
URI:	https://orca.cardiff.ac.uk/id/eprint/47330

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