An alternative beads-on-a-string chromatin architecture in Thermococcus kodakarensis

Maruyama, Hugo, Harwood, Janet C., Moore, Karen M., Paszkiewicz, Konrad, Durley, Samuel C., Fukushima, Hisaroni, Atomi, Haruyuki, Takeyasu, Kunio and Kent, Nicholas A. ORCID: https://orcid.org/0000-0002-4114-1307 2013. An alternative beads-on-a-string chromatin architecture in Thermococcus kodakarensis. Embo Reports 14 (8) , pp. 711-717. 10.1038/embor.2013.94

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Abstract

We have applied chromatin sequencing technology to the euryarchaeon Thermococcus kodakarensis, which is known to possess histone-like proteins. We detect positioned chromatin particles of variable sizes associated with lengths of DNA differing as multiples of 30 bp (ranging from 30 bp to >450 bp) consistent with formation from dynamic polymers of the archaeal histone dimer. T. kodakarensis chromatin particles have distinctive underlying DNA sequence suggesting a genomic particle-positioning code and are excluded from gene-regulatory DNA suggesting a functional organization. Beads-on-a-string chromatin is therefore conserved between eukaryotes and archaea but can derive from deployment of histone-fold proteins in a variety of multimeric forms.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH426 Genetics Q Science > QR Microbiology > QR355 Virology
Uncontrolled Keywords:	chromatin; nucleosome; histone; archaea; chromatin-seq
Publisher:	Nature Publishing Group
ISSN:	1469-221X
Last Modified:	24 Oct 2022 11:34
URI:	https://orca.cardiff.ac.uk/id/eprint/48591

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