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An alternative beads-on-a-string chromatin architecture in Thermococcus kodakarensis

Maruyama, Hugo, Harwood, Janet C., Moore, Karen M., Paszkiewicz, Konrad, Durley, Samuel C., Fukushima, Hisaroni, Atomi, Haruyuki, Takeyasu, Kunio and Kent, Nicholas A. 2013. An alternative beads-on-a-string chromatin architecture in Thermococcus kodakarensis. Embo Reports 14 (8) , pp. 711-717. 10.1038/embor.2013.94

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We have applied chromatin sequencing technology to the euryarchaeon Thermococcus kodakarensis, which is known to possess histone-like proteins. We detect positioned chromatin particles of variable sizes associated with lengths of DNA differing as multiples of 30 bp (ranging from 30 bp to >450 bp) consistent with formation from dynamic polymers of the archaeal histone dimer. T. kodakarensis chromatin particles have distinctive underlying DNA sequence suggesting a genomic particle-positioning code and are excluded from gene-regulatory DNA suggesting a functional organization. Beads-on-a-string chromatin is therefore conserved between eukaryotes and archaea but can derive from deployment of histone-fold proteins in a variety of multimeric forms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology > QR355 Virology
Uncontrolled Keywords: chromatin; nucleosome; histone; archaea; chromatin-seq
Publisher: Nature Publishing Group
ISSN: 1469-221X
Last Modified: 04 Jun 2017 05:07

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