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An alternative beads-on-a-string chromatin architecture in Thermococcus kodakarensis

Maruyama, Hugo, Harwood, Janet C., Moore, Karen M., Paszkiewicz, Konrad, Durley, Samuel C., Fukushima, Hisaroni, Atomi, Haruyuki, Takeyasu, Kunio and Kent, Nicholas A. ORCID: 2013. An alternative beads-on-a-string chromatin architecture in Thermococcus kodakarensis. Embo Reports 14 (8) , pp. 711-717. 10.1038/embor.2013.94

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We have applied chromatin sequencing technology to the euryarchaeon Thermococcus kodakarensis, which is known to possess histone-like proteins. We detect positioned chromatin particles of variable sizes associated with lengths of DNA differing as multiples of 30 bp (ranging from 30 bp to >450 bp) consistent with formation from dynamic polymers of the archaeal histone dimer. T. kodakarensis chromatin particles have distinctive underlying DNA sequence suggesting a genomic particle-positioning code and are excluded from gene-regulatory DNA suggesting a functional organization. Beads-on-a-string chromatin is therefore conserved between eukaryotes and archaea but can derive from deployment of histone-fold proteins in a variety of multimeric forms.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QH Natural history > QH426 Genetics
Q Science > QR Microbiology > QR355 Virology
Uncontrolled Keywords: chromatin; nucleosome; histone; archaea; chromatin-seq
Publisher: Nature Publishing Group
ISSN: 1469-221X
Last Modified: 24 Oct 2022 11:34

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