Möschwitzer, Vicki Doreen, Kariuki, Benson ![]() ![]() |
Official URL: http://dx.doi.org/10.1016/j.tetlet.2013.06.066
Abstract
Syntheses of amino acids with aminopyrimidine and cyclic guanidine side chains are described. The synthetic route employed Heck coupling of methyl 2-acetamidoacrylate to 4-methoxybenzyl protected 2-amino-5-iodopyrimidine, followed by Rh(I)-catalyzed asymmetric hydrogenation to afford a chiral protected amino acid. All protecting groups were removed under acidic conditions to afford the amino acid, (S)-2-amino-3-(2-aminopyrimidin-5-yl)propanoic acid, which underwent hydrogenation to afford an amino acid with a six-membered cyclic guanidine side chain.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Subjects: | Q Science > QD Chemistry |
Uncontrolled Keywords: | Amino acid; Aminopyrimidine; Guanidine; Asymmetric hydrogenation |
Publisher: | Elsevier |
ISSN: | 0040-4039 |
Funders: | EPSRC |
Last Modified: | 24 Oct 2022 11:38 |
URI: | https://orca.cardiff.ac.uk/id/eprint/48819 |
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