The neurobiology of Duchenne muscular dystrophy: learning lessons from muscle?

Blake, Derek J. ORCID: https://orcid.org/0000-0002-5005-4731 and Kröger, Stephan 2000. The neurobiology of Duchenne muscular dystrophy: learning lessons from muscle? Trends in Neurosciences 23 (3) , pp. 92-99. 10.1016/S0166-2236(99)01510-6

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Abstract

Several forms of inherited muscular dystrophy are associated with brain abnormalities and cognitive impairment. One of the most common and severe of these diseases is Duchenne muscular dystrophy (DMD). Dystrophin, the product of the DMD gene, is found in neurones, where it is associated with the postsynaptic membrane. Cognitive impairment in individuals with DMD is thought to be due to an abnormality in the neuronal membrane that is caused by lack of dystrophin. Recent experimental evidence has provided valuable clues in our understanding of the complex molecular neurobiology of muscular dystrophy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	neuroscience
Publisher:	Cell Press
ISSN:	0166-2236
Last Modified:	24 Oct 2022 11:47
URI:	https://orca.cardiff.ac.uk/id/eprint/49304

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