Two polymorphic dinucleotide repeats in the rat dystrophin gene, including the conserved 3' UTR repeat

Millwood, I. Y., Blake, Derek J. ORCID: https://orcid.org/0000-0002-5005-4731, Gauguier, D. and Monaco, A. P. 1995. Two polymorphic dinucleotide repeats in the rat dystrophin gene, including the conserved 3' UTR repeat. Mammalian Genome 6 (9) , pp. 668-669.

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Abstract

The human dystrophin (DMD) gene contains at least 79 exons, five different promoters, and spans approximately 2.5 Mb and 12 cM of the X Chromosome (Chr; Ahn and Kunkel 1993; Abbs et al. 1990). We have isolated two new polymorphic (CA), dinucleotide microsatellite repeats in the rat DMD gene, one near exon 29 towards the 5' end of the gene, the other in the 3' untranslated region. The Y (CA)n microsatellite is conserved between species, present at the same location in the rat, mouse, and human genes (Maichele and Chamberlain 1992). Both the microsatellites are polymorphic between different rat strains, making them useful markers for mapping in rat genetic crosses.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Springer Verlag
ISSN:	0938-8990
Last Modified:	24 Oct 2022 11:50
URI:	https://orca.cardiff.ac.uk/id/eprint/49490

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