Blake, Derek J.  ORCID: https://orcid.org/0000-0002-5005-4731, Schofield, Julian N., Zuellig, Richard A., Górecki, Dariusz C., Phelps, S. R., Barnard, E. A., Edwards, Y. H. and Davies, Kay E.
1995.
G-Utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain.
Proceedings of the National Academy of Sciences of the United States of America
92
(9)
, pp. 3697-3701.
10.1073/pnas.92.9.3697
|
Abstract
The utrophin gene is closely related to the dystrophin gene in both sequence and genomic structure. The Duchenne muscular dystrophy (DMD) locus encodes three 14-kb dystrophin transcripts in addition to several smaller isoforms, one of which, Dp116, is specific to peripheral nerve. We describe here the corresponding 5.5-kb mRNA from the utrophin locus. This transcript, designated G-utrophin, is of particular interest because it is specifically expressed in the adult mouse brain and appears to be the predominant utrophin transcript in this tissue. G-utrophin is expressed in brain sites generally different from the regions expressing beta-dystroglycan. During mouse embryogenesis G-utrophin is also seen in the developing sensory ganglia. Our data confirm the close evolutionary relationships between the DMD and utrophin loci; however, the functions for the corresponding proteins probably differ.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) |
| Subjects: | R Medicine > R Medicine (General) |
| Uncontrolled Keywords: | Duchenne muscular dystrophy, alternative transcript, mouse development, neuron |
| Publisher: | National Academy of Sciences |
| ISSN: | 0027-8424 |
| Last Modified: | 24 Oct 2022 11:50 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/49492 |
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