Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease

Liddell, Malcolm Brandon, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Bayer, Antony James ORCID: https://orcid.org/0000-0002-7514-248X, Kaiser, F. and Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 1994. Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease. Journal of Medical Genetics 31 (3) , pp. 197-200. 10.1136/jmg.31.3.197

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Abstract

The Apo E genotype of 86 patients with Alzheimer's disease (AD) and 77 age matched controls was determined by digestion of Apo E PCR products with the restriction enzyme CfoI. The frequency of the e4 allele was significantly increased in the patient group (0.33) as compared with controls (0.12). This effect was seen in patients with a family history and in sporadic cases. The odds ratio in homozygotes for the e4 allele was 11.24 (95% confidence interval 2.45-51.50). There was no relationship between age of onset and Apo E genotype. There was no linkage disequilibrium between the apolipoprotein E locus and a TaqI polymorphism at the Apo CII locus, and no allelic association between Apo CII and AD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Systems Immunity Research Institute (SIURI) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	R Medicine > R Medicine (General)
Publisher:	BMJ Publishing Group
ISSN:	1468-6244
Last Modified:	25 Oct 2024 01:18
URI:	https://orca.cardiff.ac.uk/id/eprint/50112

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