Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

Matsumoto, Tomoya, Rauskolb, Stefanie, Polack, Martin, Klose, Johannes, Kolbeck, Roland, Korte, Martin and Barde, Yves-Alain ORCID: https://orcid.org/0000-0002-7627-461X 2008. Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF. Nature Neuroscience 11 (2) , pp. 131-133. 10.1038/nn2038

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Abstract

Pro- and mature BDNF activate very different receptors and intracellular pathways, potentially leading to either neuronal death or survival. Here we examined the biochemistry of endogenous BDNF in mouse neurons using sensitive reagents and found that pro-BDNF is rapidly converted intracellularly to mature BDNF, the latter being stored and released by excitatory input.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH301 Biology
Publisher:	Nature Publishing Group
ISSN:	1097-6256
Last Modified:	25 Oct 2022 08:01
URI:	https://orca.cardiff.ac.uk/id/eprint/51126

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