Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array

Castell, Oliver Kieran ORCID: https://orcid.org/0000-0002-6059-8062, Berridge, James and Wallace, Mark I. 2012. Quantification of membrane protein inhibition by optical ion flux in a droplet interface bilayer array. Angewandte Chemie - International Edition 51 (13) , pp. 3134-3138. 10.1002/anie.201107343

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Abstract

Optical platforms for assaying membrane protein function offer a promising route to scalable high-throughput screening (see picture). For the first time quantitative measurements of membrane protein inhibition are reported in an optically addressable lipid bilayer array. Wide-field total internal reflection fluorescence (TIRF) imaging of Ca2+ flux enables the quantification of α-hemolysin inhibition by γ-cyclodextrin.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	arrays; high-throughput screening; lipid bilayers; membrane proteins
Publisher:	Wiley-Blackwell
ISSN:	1433-7851
Last Modified:	25 Oct 2022 08:04
URI:	https://orca.cardiff.ac.uk/id/eprint/51313

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