Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Mullins, Paul G., McGonigle, David ORCID: https://orcid.org/0000-0001-9595-6352, O'Gorman, Ruth L., Puts, Nicolaas, Vidyasagar, Rishma, Evans, Christopher John ORCID: https://orcid.org/0000-0002-6619-4245 and Edden, Richard A. E. 2014. Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA. NeuroImage 86 , pp. 43-52. 10.1016/j.neuroimage.2012.12.004

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Abstract

There is increasing interest in the use of edited proton magnetic resonance spectroscopy for the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a number of spectroscopy groups met to discuss the acquisition, analysis and interpretation of GABA-edited MR spectra. This paper aims to set out the issues discussed at this meeting, reporting areas of consensus around parameters and procedures in the field and highlighting those areas where differences remain. It is hoped that this paper can fulfill two needs, providing a summary of the current ‘state-of-the-art’ in the field of GABA-edited MRS at 3 T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Cardiff University Brain Research Imaging Centre (CUBRIC) Psychology
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	GABA; Edited MRS; MEGA-PRESS; MRS analysis
Publisher:	Elsevier
ISSN:	1053-8119
Last Modified:	25 Oct 2022 08:04
URI:	https://orca.cardiff.ac.uk/id/eprint/51327

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