Characteristics of persistent ovarian masses in asymptomatic women

Bhan, V., Amso, Nazar Najib ORCID: https://orcid.org/0000-0002-8646-6623, Whitehead, M. I., Campbell, S., Collins, W. P. and Royston, P. 1989. Characteristics of persistent ovarian masses in asymptomatic women. British Journal of Obstetrics and Gynaecology 96 (12) , pp. 1384-1391. 10.1111/j.1471-0528.1989.tb06299.x

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Abstract

Persistent ovarian masses have been found in a substantial proportion of 5479 self-selected asymptomatic women who were screened for early ovarian neoplasia. Each woman was scheduled to undergo three ultrasound screens (consisting of 1–12 scans) to detect regressing and non-regressing masses. A total of 14,594 screens (15,977 scans) was performed. The average interval between successive screens was 595 days (range 214–1134 days). Overall, 650screens (4.4%; 10.1% of women) produced a positive result which became negative with successive scans (four times more frequently in pre-than naturally postmenopausal women), and 338 screens (2.3%; 5.9% of women) had a final positive result (at least one ovary that was grossly abnormal or contained a persistent mass). Biopsies were taken from 336 ovaries (89% of total, 271 women). Overall, 134 tumour-like conditions and 119 benign tumours were identified. The detection rate of tumour-like conditions was 1.5 times higher in premenopausal than naturally postmenopausal women, whereas the proportion of tumours to normal ovaries was similar in both groups. Overall, 51% of tumour-like conditions and 70% of all tumours were detected at screen 1. Four women had metastatic ovarian cancer (three at screen 1, one at screen 2; two were bilateral). Five women (0.1%) had a primary malignant tumour (two at screen 1, three at screen 2; four were stage la and one was stage Ib). All women are being monitored to obtain additional information about the significance of the findings.

Item Type:	Article
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RG Gynecology and obstetrics
Publisher:	Wiley-Blackwell
ISSN:	0306-5456
Last Modified:	25 Oct 2022 08:15
URI:	https://orca.cardiff.ac.uk/id/eprint/52018

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