Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease [Letter]

Lambert, Jean-Charles, Ibrahim-Verbaas, Carla A., Harold, Denise ORCID: https://orcid.org/0000-0001-5195-0143, Naj, Adam C., Sims, Rebecca ORCID: https://orcid.org/0000-0002-3885-1199, Bellenguez, Céline, Jun, Gyungah, DeStefano, Anita L., Bis, Joshua C., Beecham, Gary W., Grenier-Boley, Benjamin, Russo, Giancarlo, Thornton-Wells, Tricia A., Denning, Nicola, Smith, Albert V., Chouraki, Vincent, Thomas, Charlene, Ikram, M. Arfan, Zelenika, Diana, Vardarajan, Badri N., Kamatani, Yoichiro, Lin, Chiao-Feng, Gerrish, Amy, Schmidt, Helena, Kunkle, Brian, Dunstan, Melanie ORCID: https://orcid.org/0000-0003-3817-2142, Ruiz, Agustin, Bihoreau, Marie-Thérèse, Choi, Seung-Hoan, Reitz, Christiane, Pasquier, Florence, Hollingworth, Paul, Ramirez, Alfredo, Hanon, Olivier, Fitzpatrick, Annette L., Buxbaum, Joseph D., Campion, Dominique, Crane, Paul K, Baldwin, Clinton, Becker, Tim, Gudnason, Vilmundur, Cruchaga, Carlos, Craig, David, Amin, Najaf, Berr, Claudine, Lopez, Oscar L., De Jager, Philip L., Deramecourt, Vincent, Johnston, Janet A., Evans, Denis, Lovestone, Simon, Letenneur, Luc, Morón, Francisco J., Rubinsztein, David C., Eiriksdottir, Gudny, Sleegers, Kristel, Goate, Alison M., Fiévet, Nathalie, Huentelman, Matthew J., Gill, Michael, Brown, Kristelle, Kamboh, M Ilyas, Keller, Lina, Barberger-Gateau, Pascale, McGuinness, Bernadette, Larson, Eric B., Green, Robert, Myers, Amanda J., Dufouil, Carole, Todd, Stephen, Wallon, David, Love, Seth, Rogaeva, Ekaterina, Gallacher, John Edward ORCID: https://orcid.org/0000-0002-2394-5299, St George-Hyslop, Peter, Clarimon, Jordi, Lleo, Alberto, Bayer, Antony James ORCID: https://orcid.org/0000-0002-7514-248X, Tsuang, Debby W., Yu, Lei, Tsolaki, Magda, Bossù, Paola, Spalletta, Gianfranco, Proitsi, Petroula, Collinge, John, Sorbi, Sandro, Sanchez-Garcia, Florentino, Fox, Nick C., Hardy, John, Naranjo, Maria Candida Deniz, Bosco, Paolo, Clarke, Robert, Brayne, Carol, Galimberti, Daniela, Mancuso, Michelangelo, Matthews, Fiona, Moebus, Susanne, Mecocci, Patrizia, Del Zompo, Maria, Maier, Wolfgang, Hampel, Harald, Pilotto, Alberto, Bullido, Maria, Panza, Francesco, Caffarra, Paolo, Nacmias, Benedetta, Gilbert, John R., Mayhaus, Manuel, Lannfelt, Lars, Hakonarson, Hakon, Pichler, Sabrina, Carrasquillo, Minerva M., Ingelsson, Martin, Beekly, Duane, Alvarez, Victoria, Zou, Fanggeng, Valladares, Otto, Younkin, Steven G., Coto, Eliecer, Hamilton-Nelson, Kara L., Gu, Wei, Razquin, Cristina, Pastor, Pau, Mateo, Ignacio, Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862, Faber, Kelley M., Jonsson, Palmi V., Combarros, Onofre, O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379, Cantwell, Laura B., Soininen, Hilkka, Blacker, Deborah, Mead, Simon, Mosley, Thomas H., Bennett, David A., Harris, Tamara B., Fratiglioni, Laura, Holmes, Clive, de Bruijn, Renee F. A. G., Passmore, Peter, Montine, Thomas J., Bettens, Karolien, Rotter, Jerome I., Brice, Alexis, Morgan, Kevin, Foroud, Tatiana M., Kukull, Walter A., Hannequin, Didier, Powell, John F., Nalls, Michael A., Ritchie, Karen, Lunetta, Kathryn L., Kauwe, John S. K., Boerwinkle, Eric, Riemenschneider, Matthias, Boada, Mercè, Hiltunen, Mikko, Martin, Eden R, Schmidt, Reinhold, Rujescu, Dan, Wang, Li-San, Dartigues, Jean-François, Mayeux, Richard, Tzourio, Christophe, Hofman, Albert, Nöthen, Markus M., Graff, Caroline, Psaty, Bruce M., Jones, Lesley ORCID: https://orcid.org/0000-0002-3007-4612, Haines, Jonathan L., Holmans, Peter Alan ORCID: https://orcid.org/0000-0003-0870-9412, Lathrop, Mark, Pericak-Vance, Margaret A., Launer, Lenore J., Farrer, Lindsay A., van Duijn, Cornelia M., Van Broeckhoven, Christine, Escott-Price, Valentina ORCID: https://orcid.org/0000-0003-1784-5483, Seshadri, Sudha, Williams, Julie ORCID: https://orcid.org/0000-0002-4069-0259, Schellenberg, Gerard D. and Amouyel, Philippe 2013. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease [Letter]. Nature Genetics 45 (12) , pp. 1452-1458. 10.1038/ng.2802

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Abstract

Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. We conducted a large, two-stage meta-analysis of genome-wide association studies (GWAS) in individuals of European ancestry. In stage 1, we used genotyped and imputed data (7,055,881 SNPs) to perform meta-analysis on 4 previously published GWAS data sets consisting of 17,008 Alzheimer's disease cases and 37,154 controls. In stage 2, 11,632 SNPs were genotyped and tested for association in an independent set of 8,572 Alzheimer's disease cases and 11,312 controls. In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Advanced Research Computing @ Cardiff (ARCCA) MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine Systems Immunity Research Institute (SIURI) Neuroscience and Mental Health Research Institute (NMHRI)
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > R Medicine (General)
Additional Information:	Online publication date: 27 October 2013.
Publisher:	Nature Publishing Group
ISSN:	1061-4036
Last Modified:	04 Mar 2023 02:58
URI:	https://orca.cardiff.ac.uk/id/eprint/52381

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