Ben-Sasson, S. Z., Hu-Li, J., Quiel, J., Caucheteux, Stephane, Ratner, M., Shapira, I., Dinarello, C. A. and Paul, W. E. 2009. IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation. Proceedings of the National Academy of Sciences of the United States of America 106 (17) , pp. 7119-7124. 10.1073/pnas.0902745106 |
Abstract
IL-1 causes a marked increase in the degree of expansion of naïve and memory CD4 T cells in response to challenge with their cognate antigen. The response occurs when only specific CD4 T cells can respond to IL-1β, is not induced by a series of other cytokines and does not depend on IL-6 or CD-28. When WT cells are primed in IL-1R1−/− recipients, IL-1 increases the proportion of cytokine-producing transgenic CD4 T cells, especially IL-17- and IL-4-producing cells, strikingly increases serum IgE levels and serum IgG1 levels. IL-1β enhances antigen-mediated expansion of in vitro primed Th1, Th2, and Th17 cells transferred to IL-1R1−/− recipients. The IL-1 receptor antagonist diminished responses to antigen plus lipopolysaccharide (LPS) by ≈55%. These results indicate that IL-1β signaling in T cells markedly induces robust and durable primary and secondary CD4 responses.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine |
Subjects: | R Medicine > R Medicine (General) |
Uncontrolled Keywords: | cytokines; inflammasome; Th1; Th17; Th2 |
Publisher: | National Academy of Sciences |
ISSN: | 0027-8424 |
Last Modified: | 08 Jan 2020 03:27 |
URI: | https://orca.cardiff.ac.uk/id/eprint/52734 |
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