Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos

Smith, Terence Gordon, Karlsson, Maria, Lunn, J. Simon, Eblaghie, Maxwell C., Keenan, Iain D., Farrell, Elizabeth R., Tickle, Cheryll, Storey, Kate G. and Keyse, Stephen M. 2006. Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos. FEBS Letters 580 (17) , pp. 4242-4246. 10.1016/j.febslet.2006.06.081

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Abstract

Expression of the gene encoding the MKP-3/Pyst1 protein phosphatase, which inactivates ERK MAPK, is induced by FGF. However, which intracellular signalling pathway mediates this expression is unclear, with essential roles proposed for both ERK and PI(3)K in chick embryonic limb. Here, we report that MKP-3/Pyst1 expression is sensitive to inhibition of ERK or MAPKK, that endogenous MKP-3/Pyst1 co-localizes with activated ERK, and expression of MKP-3/Pyst1 in mice lacking PDK1, an essential mediator of PI(3)K signalling. We conclude that MKP-3/Pyst1 expression is mediated by ERK activation and that negative feedback control predominates in limiting the extent of FGF-induced ERK activity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Subjects:	Q Science > QH Natural history > QH301 Biology Q Science > QH Natural history > QH426 Genetics
Uncontrolled Keywords:	Negative feedback; Fibroblast growth factor; Extracellular signal-regulated kinase; Mitogen activated protein kinase; MKP-3/Pyst1; Limb
Publisher:	Elsevier
ISSN:	0014-5793
Funders:	Royal Society
Last Modified:	03 Feb 2017 04:14
URI:	https://orca.cardiff.ac.uk/id/eprint/53366

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