Embryonic or Neural Stem Cells in Neurodegenerative Disease of the Central Nervous System (with Relevance to PD, HD, AD, MS, SCI, and Stroke)

Dunnett, Stephen Bruce ORCID: https://orcid.org/0000-0003-1826-1578, Borlongan, Cesar V. and Sanberg, Paul R. 2012. Embryonic or Neural Stem Cells in Neurodegenerative Disease of the Central Nervous System (with Relevance to PD, HD, AD, MS, SCI, and Stroke). Warwick, R. M. and Brubaker, S. A., eds. Tissue and Cell Clinical Use: An Essential Guide, Chichester: Wiley-Blackwell, pp. 358-382. (10.1002/9781118498453.ch17)

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Abstract

There has been a recent dramatic increase in understanding how to replace neurons lost through aging, trauma or disease and how to repair brain damage with significant functional recovery in a variety of models of human neurodegenerative disease. Donor factors identified in various models indicate that underlying successful cell transplantation in the nervous system critically include cell harvesting at an appropriate stage notably in embryonic or neonatal development. Also necessary are an appropriate nutritive environment for cell growth and appropriate techniques of cell implantation. Animal and other models have demonstrated the potential feasibility of using cells for repair of central nervous system disorders but for the present time functional clinical use of such cells remains an innovation in development at least in part due to the complex and precisely organized anatomical structures involved. There are also donor supply and ethics issues and conflicting clinical trial work, however, clinicians are working to achieve consensus through the application of evidence-based medicine.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QH Natural history > QH301 Biology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	neural transplantation; Parkinson's disease; Huntington's disease; multiple sclerosis; stroke; spinal cord injury; embryonic donors; neural progenitor cells; neural stem cells; brain; ES cells
Additional Information:	Online publication date: 2 August 2012.
Publisher:	Wiley-Blackwell
ISBN:	9781405198257
Related URLs:	Publisher
Last Modified:	25 Oct 2022 08:34
URI:	https://orca.cardiff.ac.uk/id/eprint/53443

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