Investigating the mechanistic basis of telomeric fusions

Heppel, Nicole H. 2011. Investigating the mechanistic basis of telomeric fusions. PhD Thesis, Cardiff University.

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Abstract

Furthermore, NBS1 deficiency results in a paucity of sporadic telomere deletion events which is consistent with the hypothesis that NBS1 is involved in the resolution of Holiday junctions within T-loops creating telomeric deletion events. In contrast, DNA Ligase IV deficiency and PARP1 inhibition caused distinct short telomere length distributions. Both these phenotypes might be related to problems with telomere replication.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Date of First Compliant Deposit:	30 March 2016
Last Modified:	19 Mar 2016 23:29
URI:	https://orca.cardiff.ac.uk/id/eprint/54200

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