Gamma-synucleinopathy in mice (and humans?)

Peters, Owen ORCID: https://orcid.org/0000-0002-6824-0663 2011. Gamma-synucleinopathy in mice (and humans?). PhD Thesis, Cardiff University.

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Abstract

As a result of these findings we assessed the distribution of gamma-synuclein in spinal cord samples of sporadic and familial amyotrophic lateral sclerosis. Though not a component of any typical ALS-associated inclusion bodies, we identified gamma-synuclein positive structures in the corticospinal tracts of several of the cases examined. All these cases shared a common pronounced loss of upper motor neurons and demyelination of the spinal cord portion of their axons. We thus propose that the unidentified gamma-synuclein positive structures represent a novel corticospinal tract inclusion structure or alternatively present a novel marker of a subtype of amyotrophic lateral sclerosis with pronounced upper motor neuron involvement.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Schools > Biosciences
Subjects:	Q Science > Q Science (General)
Date of First Compliant Deposit:	30 March 2016
Last Modified:	25 Oct 2022 08:43
URI:	https://orca.cardiff.ac.uk/id/eprint/54223

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