New consensus nomenclature for mammalian keratins

Schweizer, Jürgen, Bowden, Paul Edward, Coulombe, Pierre, Langbein, Lutz, Lane, E. Birgitte, Magin, Thomas M., Maltais, Lois, Omary, M. Bishr, Parry, David A. D., Rogers, Michael A. and Wright, Mathew W. 2006. New consensus nomenclature for mammalian keratins. Journal of Cell Biology 174 (2) , pp. 169-174. 10.1083/jcb.200603161

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Abstract

Keratins are intermediate filament–forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in recent years uncovered the existence of several novel keratin genes and their encoded proteins. Their naming could not be adequately handled in the context of the original system. We propose a new consensus nomenclature for keratin genes and proteins that relies upon and extends the 1982 system and adheres to the guidelines issued by the Human and Mouse Genome Nomenclature Committees. This revised nomenclature accommodates functional genes and pseudogenes, and although designed specifically for the full complement of human keratins, it offers the flexibility needed to incorporate additional keratins from other mammalian species.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RL Dermatology
Additional Information:	Pdf uploaded in accordance with publisher's policy at http://www.sherpa.ac.uk/romeo/issn/0021-9525/ (accessed 12/03/2014).
Publisher:	Rockefeller University Press
ISSN:	0021-9525
Date of First Compliant Deposit:	30 March 2016
Last Modified:	07 May 2023 12:31
URI:	https://orca.cardiff.ac.uk/id/eprint/55248

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