Sterol 24-methyltransferase as a drug target in parasitic protozoa

Gros, Ludovic 2005. Sterol 24-methyltransferase as a drug target in parasitic protozoa. PhD Thesis, Cardiff University.

Preview

PDF - Accepted Post-Print Version Download (52MB) | Preview

Abstract

In order to investigate further the mode of action of these compounds, synthesis of proteomic probes was attempted. Synthetic design and attempts are presented chapter VII. To establish whether there was 24-SMT present in the blood stream form of T. b. brucei, a Northern blot was carried out. This confirmed transcription of the enzyme which was then cloned, over expressed and purified (Chapter VIII). Enzyme assays were carried out against the recombinant enzyme.

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Pharmacy
Subjects:	R Medicine > RS Pharmacy and materia medica
Date of First Compliant Deposit:	30 March 2016
Last Modified:	19 Jul 2023 14:53
URI:	https://orca.cardiff.ac.uk/id/eprint/55386

Actions (repository staff only)

Edit Item