Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan

Simpson, Russell Michael 2010. Effect of cellular aging on fibroblastic phenotype and regulation by hyaluronan. PhD Thesis, Cardiff University.

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Abstract

Collectively, the data demonstrated that HA can serve as a signal integrator by facilitating TGF-beta11-mediated CD44-EGF-R-ERK interactions and ultimately regulate fibroblast phenotype. I propose a model to explain this novel mechanism and the functional consequence of age-dependent dysregulation. This mechanism may have direct implications for modifying the wound healing response, particularly for developing therapeutic strategies to improve healing in the elderly

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Date of First Compliant Deposit:	30 March 2016
Last Modified:	31 Oct 2025 16:29
URI:	https://orca.cardiff.ac.uk/id/eprint/55467

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