Analysis of telomere dynamics in human tissues

Letsolo, Boitelo Theresia 2010. Analysis of telomere dynamics in human tissues. PhD Thesis, Cardiff University.

PDF - Accepted Post-Print Version Download (26MB)

Abstract

In Barrett's oesophagus, the metaplastic tissue displayed clonal growth characterised by very short homogeneous telomere profiles compared to the adjacent normal tissue. Short telomeres and fusions were also detected in normal dermis and melanocytic naevi with evidence of clonal telomere fusion events. Such events can result in clonal expansion, which could confer selective advantage for other abnormalities that may derive neoplastic progression. These data are consistent with the view that telomere dysfunction in vivo may drive large-scale genomic instability of the type observed in early-stage neoplasia

Item Type:	Thesis (PhD)
Status:	Unpublished
Schools:	Schools > Medicine
Subjects:	Q Science > QH Natural history > QH426 Genetics R Medicine > RB Pathology
Date of First Compliant Deposit:	30 March 2016
Last Modified:	19 Mar 2016 23:32
URI:	https://orca.cardiff.ac.uk/id/eprint/55485

Actions (repository staff only)

Edit Item