Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome

Beaton, Anne E., Durnford, Andrew, Heffer-Rahn, Phillip E., Kirkham, Fenella, Griffin, Angela and Gray, William Peter 2012. Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome. Seizure - European Journal of Epilepsy 21 (9) , pp. 699-705. 10.1016/j.seizure.2012.07.012

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Abstract

Purpose This study investigates the efficacy of transylvian selective amygdalohippocampectomy (TS SAH) in children with medically intractable epilepsy due to unilateral hippocampal sclerosis. Post-surgical seizure control, intellectual and memory outcomes are examined. Method This study reports on pre- and post-surgical clinical data from 10 patients who underwent TS SAH between 2002 and 2010 after 24 months follow-up. Pre- and post-operative change in seizure frequency, AED use, intellect and memory are compared. Results At 12 months and 24 months post-surgery, 9/10 (90%) and 7/8 (87.5%) patients respectively, were seizure free (Engel I). No patients were classed as Engel III or IV. No significant improvement or decline at a group level was found on measures of intellect or verbal or visual memory. One hundred per cent improved or remained within 1 SD of their pre-operatives score on verbal and perceptual reasoning learning and reasoning measures. Significant improvement was found post-operatively for both immediate and delayed facial memory. Conclusion Our findings of good post-surgical seizure control and favourable cognitive outcome provides evidence against previous findings that SAH in children may not be effective.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Medicine
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords:	Transsylvian selective amygdalohippocampectomy; Hippocampal sclerosis; Child; Seizure; Facial memory; Epilepsy
Additional Information:	Corrigendum published in Seizure, Volume 22, Issue 5, June 2013, Pages 411, DOI: 10.1016/j.seizure.2013.02.004
Publisher:	Elsevier
ISSN:	1059-1311
Last Modified:	13 Sep 2024 01:10
URI:	https://orca.cardiff.ac.uk/id/eprint/57112

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