Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome

Beaton, Anne E., Durnford, Andrew, Heffer-Rahn, Phillip E., Kirkham, Fenella, Griffin, Angela and Gray, William Peter ORCID: https://orcid.org/0000-0001-7595-8887 2012. Transsylvian selective amygdalohippocampectomy in children with hippocampal sclerosis: Seizure, intellectual and memory outcome. Seizure - European Journal of Epilepsy 21 (9) , pp. 699-705. 10.1016/j.seizure.2012.07.012

Full text not available from this repository.

Abstract

Purpose This study investigates the efficacy of transylvian selective amygdalohippocampectomy (TS SAH) in children with medically intractable epilepsy due to unilateral hippocampal sclerosis. Post-surgical seizure control, intellectual and memory outcomes are examined. Method This study reports on pre- and post-surgical clinical data from 10 patients who underwent TS SAH between 2002 and 2010 after 24 months follow-up. Pre- and post-operative change in seizure frequency, AED use, intellect and memory are compared. Results At 12 months and 24 months post-surgery, 9/10 (90%) and 7/8 (87.5%) patients respectively, were seizure free (Engel I). No patients were classed as Engel III or IV. No significant improvement or decline at a group level was found on measures of intellect or verbal or visual memory. One hundred per cent improved or remained within 1 SD of their pre-operatives score on verbal and perceptual reasoning learning and reasoning measures. Significant improvement was found post-operatively for both immediate and delayed facial memory. Conclusion Our findings of good post-surgical seizure control and favourable cognitive outcome provides evidence against previous findings that SAH in children may not be effective.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Transsylvian selective amygdalohippocampectomy; Hippocampal sclerosis; Child; Seizure; Facial memory; Epilepsy
Additional Information: Corrigendum published in Seizure, Volume 22, Issue 5, June 2013, Pages 411, DOI: 10.1016/j.seizure.2013.02.004
Publisher: Elsevier
ISSN: 1059-1311
Last Modified: 25 Oct 2022 09:04
URI: https://orca.cardiff.ac.uk/id/eprint/57112

Citation Data

Cited 11 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item