Oretti, Rosanna, Bano, Samina, Morgan, Christopher J., Badawy, Abdulla A.-B., Bonner, Adrian, Buckland, Paul Robert and McGuffin, Peter 1996. Prevention by cycloheximide of the audiogenic seizures and tryptophan metabolic disturbances of ethanol withdrawal in rats. Alcohol and Alcoholism 31 (3) , pp. 243-247. 10.1093/oxfordjournals.alcalc.a008143 |
Official URL: http://dx.doi.org/10.1093/oxfordjournals.alcalc.a0...
Abstract
Cycloheximide (20 mg/kg body wt, given intraperitoneally at —1 and 3 h after withdrawal of an ethanol-containing liquid diet) prevents the activation of liver tryptophan pyrrolase, the consequent inhibition of synthesis of brain 5-hydroxytryptamine, and the audiogenic seizures observed at 7 h after alcohol withdrawal. We suggest that a rapidly-turning-over protein mediates the alcohol withdrawal syndrome and discuss the possible role of liver tryptophan pyrrolase.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Oxford University Press |
ISSN: | 0735-0414 |
Last Modified: | 05 Feb 2020 03:35 |
URI: | https://orca.cardiff.ac.uk/id/eprint/57455 |
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