Prevention by cycloheximide of the audiogenic seizures and tryptophan metabolic disturbances of ethanol withdrawal in rats

Oretti, Rosanna, Bano, Samina, Morgan, Christopher J., Badawy, Abdulla A.-B., Bonner, Adrian, Buckland, Paul Robert and McGuffin, Peter 1996. Prevention by cycloheximide of the audiogenic seizures and tryptophan metabolic disturbances of ethanol withdrawal in rats. Alcohol and Alcoholism 31 (3) , pp. 243-247. 10.1093/oxfordjournals.alcalc.a008143

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Abstract

Cycloheximide (20 mg/kg body wt, given intraperitoneally at —1 and 3 h after withdrawal of an ethanol-containing liquid diet) prevents the activation of liver tryptophan pyrrolase, the consequent inhibition of synthesis of brain 5-hydroxytryptamine, and the audiogenic seizures observed at 7 h after alcohol withdrawal. We suggest that a rapidly-turning-over protein mediates the alcohol withdrawal syndrome and discuss the possible role of liver tryptophan pyrrolase.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Oxford University Press
ISSN:	0735-0414
Last Modified:	05 Feb 2020 03:35
URI:	https://orca.cardiff.ac.uk/id/eprint/57455

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