A structure for the porcine TSH receptor

Kajita, Yoshihiro, Rickards, Carole R., Buckland, Paul Robert, Howells, Roger David and Rees Smith, Bernard 1985. A structure for the porcine TSH receptor. FEBS Letters 181 (2) , pp. 218-222. 10.1016/0014-5793(85)80263-5

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Abstract

Affinity purified, detergent-solubilised porcine TSH receptors have been crosslinked to a 125I-labelled photoactive derivative of TSH and analysed by gel electrophoresis, gel filtration and sucrose density gradient centrifugation. Our studies suggest that the porcine TSH receptor is made up of a hydrophilic A subunit with an Mr about 45000 linked to an amphiphilic B subunit (Mrapprox. 25 000) by a disulphide bridge(s). The A subunit forms the binding site for TSH on the outside of the cell membrane. The B subunit appears to penetrate the membrane and form the site for interaction with adenylate cyclase either in the lipid bilayer or close to the cytoplasmic surface of the membrane.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Schools > Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0014-5793
Last Modified:	12 Dec 2022 08:47
URI:	https://orca.cardiff.ac.uk/id/eprint/57647

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