Photoinitiated synthesis of self-assembled vesicles

Griffith, Elizabeth C., Rapf, Rebecca J., Shoemaker, Richard K., Carpenter, Barry K. ORCID: https://orcid.org/0000-0002-5470-0278 and Vaida, Veronica 2014. Photoinitiated synthesis of self-assembled vesicles. Journal of the American Chemical Society 136 (10) , pp. 3784-3787. 10.1021/ja5006256

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Abstract

The aqueous photochemistry of 2-oxooctanoic acid (a single-tailed surfactant) results in the synthesis of a double-tailed surfactant product followed by spontaneous self-assembly into vesicles. The photochemical mechanism is detailed here, and the reaction products are identified using mass spectrometry. Then, the self-assembled vesicles are characterized using dynamic light scattering, fluorescence microscopy, and NMR. Further, their stability over time and in the presence of MgCl2 salt is demonstrated. This work contributes to membrane evolution through the provision of a prebiotic route for the synthesis of plausible membrane components and subsequent self-assembly of a primitive enclosure.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Advanced Research Computing @ Cardiff (ARCCA) Chemistry
Subjects:	Q Science > QD Chemistry
Additional Information:	Online publication date: 24 February 2014.
Publisher:	American Chemical Society
ISSN:	0002-7863
Funders:	NSF
Last Modified:	25 Oct 2022 09:14
URI:	https://orca.cardiff.ac.uk/id/eprint/57777

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