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No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder

Bowen, Timothy ORCID:, Ashworth, Lindsay, Kirov, George ORCID:, Guy, Carol, Jones, Ian Richard ORCID:, McCandless, Fiona, Craddock, Nicholas John ORCID:, O'Donovan, Michael Conlon ORCID: and Owen, Michael John ORCID: 2000. No evidence of association from transmission disequilibrium analysis of the hKCa3 gene in bipolar disorder. Bipolar Disorders 2 (4) , pp. 328-331. 10.1034/j.1399-5618.2000.020406.x

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OBJECTIVE: A recent case control study has suggested that modest enlargements of a highly polymorphic CAG repeat in exon 1 of the gene encoding potassium channel hKCa3 may be associated with bipolar disorder (BPD). We have examined this hypothesis by genotyping this locus in a family-based association study. METHOD: One hundred and twenty-eight parent offspring trios of British Caucasian origin were examined where the proband was diagnosed with the American Psychiatric Association's Diagnostic and Statistical Manual (DSM)-IV BPD I (n = 123) or II (n = 5). An improved assay was used, with redesigned polymerase chain reaction (PCR) primers, permitting quicker and higher resolution genotyping. The resultant genotypes were analysed using the extended transmission/ disequilibrium test (ETDT). RESULTS: The experimental data did not provide evidence for the preferential transmission of large alleles to bipolar cases (chi2 = 11.12, df = 10, p = 0.349). CONCLUSIONS: Our data provide no support for the hypothesis that variation at the hKCa3 gene contributes to susceptibility to BPD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: bipolar disorder; hKCa3; human potassium channel gene; polymorphic CAG repeat
Publisher: Wiley-Blackwell
ISSN: 1398-5647
Last Modified: 12 Dec 2022 08:52

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