Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains

Oretti, Rossana G., Spurlock, Gillian, Buckland, Paul Robert and McGuffin, Peter 1994. Lack of effect of antipsychotic and antidepressant drugs on glutamate receptor mRNA levels in rat brains. Neuroscience Letters 177 (1-2) , pp. 39-43. 10.1016/0304-3940(94)90039-6

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Abstract

By employing multiprobe oligonucleotide solution hybridisation (MOSH) we have measured the levels of mRNA encoding the NMDA receptor subtypes (R1, R2A, R2B and R2C) and the non-NMDA glutamate receptor subtypes (GluR1, 2, 3, and 4) within rat brain following, 1–32 days of antipsychotic or antidepressant drug administration. The results suggest that the drugs studied do not significantly alter rat glutamatergic system mRNA levels when compared to controls.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
ISSN:	0304-3940
Last Modified:	12 Dec 2022 08:53
URI:	https://orca.cardiff.ac.uk/id/eprint/57891

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