Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels

Buckland, Paul Robert, Spurlock, Gillian and McGuffin, Peter 1996. Amphetamine and vigabatrin down regulate aromatic l-amino acid decarboxylase mRNA levels. Molecular Brain Research 35 (1-2) , pp. 69-76. 10.1016/0169-328X(95)00182-R

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Abstract

Aromatic l-amino acid decarboxylase (AADC) has previously been shown to be up-regulated at the level of its protein activity and its mRNA abundance by antipsychotic drugs. Its activity has also been shown to be down-regulated by dopamine agonists including amphetamine. In this study we have injected rats for up to 32 days with amphetamine and the anti-epileptic drug vigabatrin, both of which can cause psychosis with similarities to schizophrenia. We have shown that AADC mRNA levels are reduced in most brain regions by both drugs. Cocaine and other non-psychotogenic anti-epileptic drugs had no effect in this paradigm. Two products of this enzyme are implicated in psychotogenesis.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0169-328X
Last Modified:	12 Dec 2022 08:53
URI:	https://orca.cardiff.ac.uk/id/eprint/57892

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