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Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia

Bowen, Timothy ORCID:, Guy, Carol, Craddock, Nicholas John ORCID:, Cardno, A. G., Williams, Nigel Melville ORCID:, Spurlock, G., Murphy, K. C., Jones, L. A., Gray, M., Sanders, Rebecca, McCarthy, G, Chandy, K. G., Fantino, E, Kalman, K, Gutman, G. A., Gargus, J. J., Williams, Julie ORCID:, McGuffin, P., Owen, Michael John ORCID: and O'Donovan, Michael Conlon ORCID: 1998. Further support for an association between a polymorphic CAG repeat in the hKCa3 gene and schizophrenia. Molecular Psychiatry 3 (3) , pp. 266-269. 10.1038/

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A recent study has suggested that a polymorphism in the hKCa3 potassium channel may be associated with raised susceptibility to schizophrenia. Despite its modest statistical significance, the study is intriguing for two reasons. First, hKCa3 contains a polymorphic CAG repeat in its coding sequence, with large repeats more common in schizophrenics compared with controls. This is interesting in view of several repeat expansion detection (RED) studies that have reported an excess of large CAG repeats in psychotic probands. Second, the hKCa3 gene is a functional candidate gene because studies of antipsychotic and psychotogenic compounds suggest that glutamatergic systems modulated by SKCa channels may be important in schizophrenia pathogenesis. In the light of the above, we have tested the hypothesis of an association between schizophrenia and the hKCa3 CAG repeat polymorphism using a case control study design. Under the same model of analysis as the earlier study, schizophrenic probands had a higher frequency of alleles with greater than 19 repeats than controls (chi 2 = 2.820, P = 0.047, 1-tail). Our data therefore provide modest support for the hypothesis that polymorphism in the hKCa3 gene may contribute to susceptibility to schizophrenia.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Alleles; Case Control Studies; Female; Genotype; Humans; Male; MiddleAged; Polymorphism; Genetic*; Potassium Channels / genetics; Schizophrenia / genetics*; Trinucleotide Repeats* Substances Potassium Channels
Additional Information: Publication Types Research Support, Non-U.S. Gov't Grant Support Wellcome Trust/United Kingdom Full Text Sources EBSCO Other Literature Sources COS Scholar Universe Labome Researcher Resource - ExactAntigen/Labome Medical Schizophrenia - MedlinePlus Health Information
Publisher: Nature Publishing Group
ISSN: 1359-4184
Last Modified: 12 Dec 2022 08:55

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