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Association between functional psychosis and expanded CAG/CTG repeats is not explained by health stratification [comparative study]

Cardno, A. G., McCandless, F., Bowen, Timothy ORCID:, Guy, Carol, Jones, L. A., Murphy, Kevin, McGuffin, P., Owen, Michael John ORCID:, Craddock, Nicholas John ORCID: and O'Donovan, Michael Conlon ORCID: 1998. Association between functional psychosis and expanded CAG/CTG repeats is not explained by health stratification [comparative study]. Psychiatric Genetics 8 (1) , pp. 29-32. 10.1097/00041444-199800810-00005

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A number of studies have reported an association between large CAG/CTG repeats and both schizophrenia and bipolar disorder. Recently, we reported an inverse correlation between CAG/CTG repeat size and age in a health-selected population, raising the possibility that selection of control groups for physical health was a confounding factor in our previous association studies. We investigated this by health-selection of patients with schizophrenia and bipolar disorder. The maximum CAG/CTG repeat size remained significantly larger in probands with functional psychosis compared with control individuals, and in probands with a diagnosis of schizophrenia compared with control individuals. The number of probands in the healthy bipolar group was small, and although on average this group also had longer CAG/CTG repeats than control individuals, this failed to reach statistical significance. Our findings do not support the notion that the original results with psychosis as a whole, and schizophrenia specifically, are attributable to a stratification effect consequent on health selection. Nevertheless, we are unable formally to reject the hypothesis that the previously observed difference between bipolar probands and control individuals is the result of this phenomenon.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Bipolar Disorder / classification, Bipolar Disorder / genetics*, Humans, Patient Selection, Reference Values, Schizophrenia / classification, Schizophrenia / genetics*, Trinucleotide Repeats*
Additional Information: Publication Types Comparative Study Research Support, Non-U.S. Gov't Full Text Sources Ovid Technologies, Inc. Other Literature Sources COS Scholar Universe Medical Bipolar Disorder - MedlinePlus Health Information Schizophrenia - MedlinePlus Health Information
Publisher: Lippincott and Williams
ISSN: 0955-8829
Last Modified: 12 Dec 2022 08:55

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