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Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder

O'Donovan, Michael Conlon ORCID:, Guy, Carol, Craddock, Nicholas John ORCID:, Bowen, Timothy ORCID:, McKeon, P., Macedo, A., Maier, W., Wildenauer, D., Aschauer, H. N., Sorbi, S., Feldman, E., Mynett-Johnson, L., Claffey, E., Nacmias, B., Valente, J., Dourado, A., Grassi, E., Lenzinger, E., Heiden, A. M., Moorhead, S., Harrison, D., Williams, Julie ORCID:, McGuffin, P. and Owen, Michael John ORCID: 1996. Confirmation of association between expanded CAG/CTG repeats and both schizophrenia and bipolar disorder. Psychological Medicine -London- 26 (6) , pp. 1145-1153. 10.1017/s0033291700035868

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Recent studies have suggested that expanded CAG/CTG repeats contribute to the genetic aetiology of schizophrenia and bipolar disorder. However, the nature of this contribution is uncertain and difficult to predict from other known trinucleotide repeat diseases that display much simpler patterns of inheritance. We have sought to replicate and extend earlier findings using Repeat Expansion Detection in an enlarged sample of 152 patients with schizophrenia, 143 patients with bipolar disorder, and 160 controls. We have also examined DNA from the parents of 62 probands with schizophrenia or bipolar disorder. Our results confirm our earlier, preliminary findings of an association between expanded trinucleotide repeats and both schizophrenia and bipolar disorder. However, our data do not support the hypothesis that trinucleotide repeat expansion can alone explain the complex patterns of inheritance of the functional psychoses neither can this mechanism fully explain apparent anticipation

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Adult, Bipolar Disorder / genetics*, Case-Control Studies, DNA / genetics*, Europe, Family Health,Female,Humans, Logistic Models, Male, Sampling Studies, Schizophrenia / genetics*, Trinucleotide Repeats / genetics* Substances DNA
Additional Information: Publication Types Research Support, Non-U.S. Gov't Grant Support Wellcome Trust/United Kingdom Full Text Sources Ovid Technologies, Inc. Other Literature Sources COS Scholar Universe Medical Bipolar Disorder - MedlinePlus Health Information Schizophrenia - MedlinePlus Health Information
Publisher: Cambridge University Press
ISSN: 0033-2917
Last Modified: 12 Dec 2022 08:56

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