Bowen, Timothy  ORCID: https://orcid.org/0000-0001-6050-0435, Guy, Carol, Speight, G., Jones, L., Cardno, A., Murphy, Kevin, McGuffin, P., Owen, Michael John ORCID: https://orcid.org/0000-0003-4798-0862 and O'Donovan, Michael Conlon ORCID: https://orcid.org/0000-0001-7073-2379
1996.
Expansion of 50 CAG/CTG repeats excluded in schizophrenia by application of a highly efficient approach using repeat expansion detection and a PCR screening set.
American Journal of Human Genetics
59
(4)
, pp. 912-917.
|
Abstract
Studies of the transmission of schizophrenia in families with affected members in several generations have suggested that an expanded trinucleotide repeat mechanism may contribute to the genetic inheritance of this disorder. Using repeat expansion detection (RED), we and others have previously found that the distribution of CAG/CTG repeat size is larger in patients with schizophrenia than in controls. In an attempt to identify the specific expanded CAG/CTG locus or loci associated with schizophrenia, we have now used an approach based on a CAG/CTG PCR screening set combined with RED data. This has allowed us to minimize genotyping while excluding 43 polymorphic autosomal loci and 7 X-chromosomal loci from the screening set as candidates for expansion in schizophrenia with a very high degree of confidence.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Neuroscience and Mental Health Research Institute (NMHRI) |
| Subjects: | R Medicine > R Medicine (General) |
| Publisher: | American Society of Human Genetics |
| ISSN: | 0002-9297 |
| Related URLs: | |
| Last Modified: | 12 Dec 2022 08:56 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/58023 |
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