Acute myeloid leukemia: therapeutic indications [Review]

Burnett, Alan Kenneth, Kell, William Jonathan and Rowntree, Claire 2000. Acute myeloid leukemia: therapeutic indications [Review]. Current Opinion in Hematology 7 (6) , pp. 333-338. 10.1097/00062752-200011000-00002

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Abstract

The main issue for younger patients with acute myeloid leukemia is the prevention of relapse. About 55% of patients relapse and the risk can partially be predicted by prognostic factors, particularly cytogenetics. A number of strategies can attempt to reduce the relapse risk. Intensification of induction therapy has been attempted but there is as yet no convincing evidence that survival is improved. Transplantation of either allogeneic or autologous stem cells does not seem to offer major survival advantage overall or within risk groups. Improved understanding of resistance mechanisms and the identification of new risk factors may enable the development of a more targeted approach to therapy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	Acute Disease,Age Factors,Humans,Leukemia Myeloid*/diagnosis,Leukemia, Myeloid*/therapy,Prognosis,Remission Induction/methods,Risk Factors
Additional Information:	Full Text Sources Lippincott Williams & Wilkins Ovid Technologies, Inc. Other Literature Sources Labome Researcher Resource - ExactAntigen/Labome
Publisher:	Lippincott Williams & Wilkins
ISSN:	1065-6251
Last Modified:	12 Feb 2022 10:50
URI:	https://orca.cardiff.ac.uk/id/eprint/58431

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