Effects of the scleral collagen structure on the biomechanical response of the optic nerve head

Coudrillier, Baptiste, Boote, Craig ORCID: https://orcid.org/0000-0003-0348-6547 and Nguyen, Thao D. 2012. Effects of the scleral collagen structure on the biomechanical response of the optic nerve head. Presented at: ASME 2012 Summer Bioengineering Conference, Fajardo, Puerto Rico, 20-23 June 2012. Proceedings of the ASME Summer Bioengineering Conference--2012 : presented at ASME 2012 Summer Bioengineering Conference, June 20-23, 2012, Fajardo, Puerto Rico. New York, N.Y.: ASME, pp. 513-514. 10.1115/SBC2012-80540

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Abstract

The sclera is a fiber-reinforced material composed of dense superimposed lamellae of type I collagen fibrils embedded in a matrix of elastin and proteoglycan. Recent Wide-Angle X-ray Scattering (WAXS) experiments (Meek, 2009) showed that the collagen lamellae are strongly aligned circumferentially in the region closest to the optic nerve head (ONH). The collagen structure was more disperse and heterogeneous away from the peripapillary region. The collagen structure of the sclera directly influences its material stiffness properties and therefore the level of strain transmitted to the tissues of the ONH, which is the primary site of damage in glaucoma. The effects of the fiber structure on the ONH biomechanics have been studied on the monkey eye (Girard, 2009), but not on the human eye. Recent work evaluating the influence of the human sclera on ONH biomechanics approximated the scleral behavior as linear elastic (Sigal, 2009) or hyperelastic orthotropic (Eilaghi, 2009).

Item Type:	Conference or Workshop Item (Paper)
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Publisher:	ASME
ISBN:	9780791844809
Last Modified:	25 Oct 2022 09:27
URI:	https://orca.cardiff.ac.uk/id/eprint/58552

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