Refractory anaemia with preleukaemic polyclonal haemopoiesis and the emergence of monoclonal erythropoiesis on disease progression

Culligan, Dominic J., Bowen, David T., May, Alison, White, Denise, Padua, Rose Ann and Burnett, Alan Kenneth 1995. Refractory anaemia with preleukaemic polyclonal haemopoiesis and the emergence of monoclonal erythropoiesis on disease progression. British Journal of Haematology 89 (3) , pp. 675-677. 10.1111/j.1365-2141.1995.tb08389.x

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Abstract

We describe a young woman with a myelodysplastic syndrome (MDS) of the type refractory anaemia (RA) which remained stable for 11 years and then underwent rapid progression manifested by bone marrow failure with the emergence of a complex clonal cytogenetic abnormality. Peripheral blood granulocytes. mononuclear cells and bone marrow erythro-blasts were all polyclonal by X-inactivation analysis detected by the probe M27B during the preleukaemic phase. On disease progression, bone marrow erythroblasts developed an extremely skewed monoclonal pattern of X-inactivation. In some cases of MDS, therefore, polyclonal haemopoiesis can be detected for a considerable time during the preleukaemic phase and we report the demonstration of bone marrow erythroblasts changing from a polyclonal to a monoclonal pattern on disease progression.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RC Internal medicine
Uncontrolled Keywords:	myelodysplasia; erythropoiesis; polyclonality; M27B; progression
Publisher:	Wiley-Blackwell
ISSN:	0007-1048
Last Modified:	25 Jun 2017 04:42
URI:	https://orca.cardiff.ac.uk/id/eprint/58942

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