Haemostatic and fibrinolytic responses to bone marrow transplantation

Brown, S. A., Davies, S. V., Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, West, Robert Raynard, Giddings, J., Whittaker, J. and Burnett, Alan Kenneth 1999. Haemostatic and fibrinolytic responses to bone marrow transplantation. British Journal of Haematology 104 (3) , pp. 468-474. 10.1046/j.1365-2141.1999.01223.x

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Abstract

Thrombin and plasmin activation markers were serially measured in 80 patients undergoing bone marrow transplantation (BMT). There were prothrombotic and fibrinolytic responses observed during autograft and allograft BMTs. Thrombin-antithrombin and prothrombin fragment F1+2 levels increased from day -7 to -3 (P<0.0001) from 3.7 to 7 ng/ml and 1.2 to 1.63 nmol/l, respectively. A rise in plasmin-antiplasmin levels occurred between days 4 and 14 (P< 0.0004), from 393 ng/ml on day -7 to a peak of 795 ng/ml on day 11. No correlation between reduced protein C levels post-BMT and a prothrombotic state was observed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	bone marrow transplantation; prothrombotic state; fibrinolysis; protein C
Publisher:	Wiley-Blackwell
ISSN:	0007-1048
Last Modified:	25 Oct 2022 09:32
URI:	https://orca.cardiff.ac.uk/id/eprint/58975

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