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Haemostatic and fibrinolytic responses to bone marrow transplantation

Brown, S. A., Davies, S. V., Fegan, Christopher Daniel ORCID: https://orcid.org/0000-0001-9685-0621, West, Robert Raynard, Giddings, J., Whittaker, J. and Burnett, Alan Kenneth 1999. Haemostatic and fibrinolytic responses to bone marrow transplantation. British Journal of Haematology 104 (3) , pp. 468-474. 10.1046/j.1365-2141.1999.01223.x

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Abstract

Thrombin and plasmin activation markers were serially measured in 80 patients undergoing bone marrow transplantation (BMT). There were prothrombotic and fibrinolytic responses observed during autograft and allograft BMTs. Thrombin-antithrombin and prothrombin fragment F1+2 levels increased from day -7 to -3 (P<0.0001) from 3.7 to 7 ng/ml and 1.2 to 1.63 nmol/l, respectively. A rise in plasmin-antiplasmin levels occurred between days 4 and 14 (P< 0.0004), from 393 ng/ml on day -7 to a peak of 795 ng/ml on day 11. No correlation between reduced protein C levels post-BMT and a prothrombotic state was observed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: bone marrow transplantation; prothrombotic state; fibrinolysis; protein C
Publisher: Wiley-Blackwell
ISSN: 0007-1048
Last Modified: 25 Oct 2022 09:32
URI: https://orca.cardiff.ac.uk/id/eprint/58975

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