Homozygous MHC genotypes and longevity

Dorak, M. Trevfik, Mills, Kenneth Ian, Gaffney, D., Wilson, D. W., Galbraith, I., Henderson, N. and Burnett, Alan Kenneth 1994. Homozygous MHC genotypes and longevity. Human Heredity 44 (5) , pp. 271-278. 10.1159/000154229

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Abstract

To investigate the relevance of the major histocompatibility complex (MHC) in longevity, we carried out a molecular analysis of the MHC in 432 unrelated healthy individuals. The comparison of individuals < or = 25 years and > 25 years showed that the 5.8-kb DQA1 allele, which corresponds to HLA-DR53, was negatively associated with longevity (p = 0.0035) resulting mainly from decreased homozygosity with age for that allele (p = 0.008), and restricted to males (p = 0.008). The difference was more striking for the 5.8 kb DQA1: 9.0 kb HSP70 haplotype again only in males (26.3 vs. 6.2%; p = 0.017, OR = 5.4, 95% CI = 1.5 - 19.5). The oldest male subject homozygous for this DQA1: HSP70 haplotype was 54 years (p = 0.005). Comparing leukemic patients and healthy individuals with the same ethnic and geographical origin, homozygosity for these genotypes was more frequent in the young leukemic group. The results suggested the existence of recessive deleterious genes in a segment of HLA-DR53 haplotypes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Adult, Age Factors, Aged, Alleles, Female,G ene Frequency, HLADQ Antigens / genetics, HLADQ alpha Chains, Homozygote*, Humans, Longevity / genetics*, Major Histocompatibility Complex / genetics*, Male, Middle Aged Substances HLA-DQ Antigens,HLA-DQ alpha-Chains,HLA-DQA1 antigen
Additional Information:	Publication Types Research Support, Non-U.S. Gov't Other Literature Sources COS Scholar Universe
Publisher:	Karger
ISSN:	0001-5652
Last Modified:	31 Jan 2020 05:15
URI:	https://orca.cardiff.ac.uk/id/eprint/59001

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