Cote, M., Hughes, C. E., Austin, T. K., Rogueda, P. G. A., Pan, Z. G., Harris, Kenneth David Maclean ![]() |
Abstract
We report several aspects of the characterization of a material (triacetylated-β-cyclodextrin) that exists in two crystalline polymorphic forms (denoted I and II). A striking feature of this polymorphic system is that polymorph I (MPt 194 °C) and polymorph II (MPt 219 °C) exhibit remarkably different solubility in the fluorinated solvent 2H,3H-decafluoropentane, with the solubility higher by a factor of ca. eight for polymorph I at ambient temperature. Structural information established from powder X-ray diffraction and high-resolution solid-state 13C NMR spectroscopy for polymorphs I and II is reported, including crystal structure determination of polymorph II from the powder X-ray diffraction data. Differential scanning calorimetry and high-temperature powder X-ray diffraction demonstrate that the metastable polymorph I converts to the stable polymorph II over a range of elevated temperatures. The combined evidence of these and other techniques suggests that there is a monotropic relationship between polymorphs I and II.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Advanced Research Computing @ Cardiff (ARCCA) Chemistry |
Subjects: | Q Science > QD Chemistry |
Publisher: | ACS Publications |
ISSN: | 1932-7447 |
Last Modified: | 17 Oct 2022 09:50 |
URI: | https://orca.cardiff.ac.uk/id/eprint/5903 |
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