Noninvasive assessment of arterial compliance of human cerebral arteries with short inversion time arterial spin labeling

Warnert, Esther A.H., Murphy, Kevin ORCID: https://orcid.org/0000-0002-6516-313X, Hall, Judith E. ORCID: https://orcid.org/0000-0002-6770-7372 and Wise, Richard G. ORCID: https://orcid.org/0000-0003-1700-2144 2015. Noninvasive assessment of arterial compliance of human cerebral arteries with short inversion time arterial spin labeling. Journal of Cerebral Blood Flow and Metabolism 35 (3) , pp. 461-468. 10.1038/jcbfm.2014.219

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Abstract

A noninvasive method of assessing cerebral arterial compliance (AC) is introduced in which arterial spin labeling (ASL) is used to measure changes in arterial blood volume (aBV) occurring within the cardiac cycle. Short inversion time pulsed ASL (PASL) was performed in healthy volunteers with inversion times ranging from 250 to 850 ms. A model of the arterial input function was used to obtain the cerebral aBV. Results indicate that aBV depends on the cardiac phase of the arteries in the imaging volume. Cerebral AC, estimated from aBV and brachial blood pressure measured noninvasively in systole and diastole, was assessed in the flow territories of the basal cerebral arteries originating from the circle of Willis: right and left middle cerebral arteries (RMCA and LMCA), right and left posterior cerebral arteries (RPCA and LPCA), and the anterior cerebral artery (ACA). Group average AC values calculated for the RMCA, LMCA, ACA, RPCA, and LPCA were 0.56%±0.2%, 0.50%±0.3%, 0.4%±0.2%, 1.1%±0.5%, and 1.1%±0.3% per mm Hg, respectively. The current experiment has shown the feasibility of measuring AC of cerebral arteries with short inversion time PASL.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Neuroscience and Mental Health Research Institute (NMHRI) Physics and Astronomy Medicine Cardiff University Brain Research Imaging Centre (CUBRIC)
Subjects:	R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Additional Information:	This work is licensed under a Creative Commons Attribution 3.0 Unported License.
Publisher:	SAGE Publications
ISSN:	0271-678X
Funders:	Wellcome Trust
Date of First Compliant Deposit:	17 April 2020
Date of Acceptance:	3 November 2014
Last Modified:	23 May 2024 01:08
URI:	https://orca.cardiff.ac.uk/id/eprint/59057

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