Anti-transglutaminase 6 antibodies in children and young adults with cerebral palsy

Stenberg, Reidun, Hadjivassiliou, Marios, Aeschlimann, Pascale, Hoggard, Nigel and Aeschlimann, Daniel ORCID: https://orcid.org/0000-0003-0930-7706 2014. Anti-transglutaminase 6 antibodies in children and young adults with cerebral palsy. Autoimmune Diseases 2014 , pp. 1-8. 10.1155/2014/237107

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Abstract

Objectives: We have previously reported a high prevalence of gluten-related serological markers (GRSM) in children and young adults with cerebral palsy (CP). The majority had no enteropathy to suggest coeliac disease (CD). Antibodies against transglutaminase 6 (anti-TG6) represent a new marker associated with gluten-related neurological dysfunction. The aim of this study was to investigate the prevalence of anti-TG6 antibodies in this group of individuals with an early neurological injury resulting in CP. Materials and Methods. Sera from 96 patients with CP and 36 controls were analysed for IgA/IgG class anti-TG6 by ELISA. Results. Anti-TG6 antibodies were found in 12/96 (13%) of patients with CP compared to 2/36 (6%) in controls. The tetraplegic subgroup of CP had a significantly higher prevalence of anti-TG6 antibodies 6/17 (35%) compared to the other subgroups and controls. There was no correlation of anti-TG6 autoantibodies with seropositivity to food proteins including gliadin. Conclusions. An early brain insult and associated inflammation may predispose to future development of TG6 autoimmunity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Subjects:	R Medicine > R Medicine (General)
Publisher:	SAGE-Hindawi Access to Research
ISSN:	2090-0430
Funders:	Coeilac UK, Bardhan Research and Education Trust of Rotherham UK, Sheffield Hospital Trust, Örebro County Council, Sweden, Norrbacka-Eugeniastiftelsen, Sweden
Date of First Compliant Deposit:	30 March 2016
Date of Acceptance:	17 February 2014
Last Modified:	25 Oct 2022 09:33
URI:	https://orca.cardiff.ac.uk/id/eprint/59096

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