Role of allogeneic and autologous hematopoietic stem cell transplantation in acute myeloid leukemia

Burnett, Alan, Kell, William Jonathan and Rowntree, Claire 2000. Role of allogeneic and autologous hematopoietic stem cell transplantation in acute myeloid leukemia. International Journal of Hematology 72 (3) , pp. 280-284.

Full text not available from this repository.

Abstract

Most younger patients with acute myeloid leukemia will enter remission of disease. Prevention of relapse is now the central therapeutic issue. A number of factors predict the risk of relapse, the most powerful of which is cytogenetics. Both allogeneic and autologous transplantation have been extensively used as remission consolidation, but intensive chemotherapy has also provided improved results such that the choice of consolidation treatment is not clear. Recent prospective trials of allogeneic and autologous transplantation with careful analysis have not always shown a survival benefit, although both approaches have significantly reduced relapse risk. In analysis where relapse risk is taken into account based on cytogenetics, there is little evidence of the benefit of transplantation in good-risk patients, partly because patients in this group who relapse can then undergo successful salvage therapy. The results are still uncertain in standard-risk patients, so transplantation should continue to be used in the context of a trial. Poor-risk patients have a higher failure rate after transplantation, and for these patients novel approaches are required.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Publisher:	Elsevier
ISSN:	0925-5710
Related URLs:	http://www.ncbi.nlm.nih.gov/pubmed/11185...
Last Modified:	12 Feb 2022 11:05
URI:	https://orca.cardiff.ac.uk/id/eprint/59205

Citation Data

Cited 5 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item