The development of allergy in high-risk children

Burr, Michael Leslie, Merrett, T. G., Dunstan, Frank David ORCID: https://orcid.org/0000-0002-1043-5281 and Maguire, M. J. 1997. The development of allergy in high-risk children. Clinical and Experimental Allergy 27 (11) , pp. 1247-1253. 10.1111/j.1365-2222.1997.tb01168.x

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Abstract

BACKGROUND: It is uncertain as to what extent the development of allergic disease in childhood is predictable during early infancy. A number of environmental factors have been suspected of increasing the risk of acquiring allergy, but the evidence is conflicting. OBJECTIVE: To observe the development of atopy and allergic disease in a cohort of high-risk children so as to determine the importance of certain environmental factors and to study the relationship between early and later manifestations. METHODS: A cohort of infants, all at high risk of allergy, was followed up from birth to the age of 7 years. In half, selected at random, cow's milk protein was avoided for 4 months. Skin-prick tests were performed and serum IgE measured in infancy and at 7 years, when an AlaTOP test was also performed. RESULTS: Skin sensitivity to egg in the first year of life was strongly associated with eczema, asthma, mite sensitivity and serum IgE at the age of 7 years, when mother's atopic history was associated with AlaTOP status, father's atopic history with skin sensitivity, and male sex with both. Maternal smoking during pregnancy was associated positively with IgE at 3 months and negatively with skin sensitivity at 7 years. The development of allergy was unrelated to infant feeding method or number of older siblings. CONCLUSION: Allergic disease in childhood is to a large degree determined before birth or during infancy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Subjects:	R Medicine > R Medicine (General) R Medicine > RZ Other systems of medicine
Uncontrolled Keywords:	Age Factors; Animals; Child; Child Preschool; Cohort Studies; Eggs; emale; Humans; Hypersensitivity Immediate / etiology*; Hypersensitivity Immediate / genetics; Hypersensitivity Immediate / immunology; Immunoglobulin E/immunology; Infant; Infant Newborn; Male, Milk / adverse effects*; Milk / immunology; Sex Factors; Skin Tests Substances Immunoglobulin E
Additional Information:	Publication Types Comparative Study Research Support, Non-U.S. Gov't Full Text Sources EBSCO Ovid Technologies, Inc. Other Literature Sources COS Scholar Universe
Publisher:	Wiley-Blackwell
ISSN:	0954-7894
Last Modified:	25 Oct 2022 09:35
URI:	https://orca.cardiff.ac.uk/id/eprint/59224

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