An observational study of empirical antibiotics for adult women with uncomplicated UTI in general practice

O'Brien, Kathryn, Hillier, Sharon, Simpson, Sharon Anne, Hood, Kerenza ORCID: https://orcid.org/0000-0002-5268-8631 and Butler, Christopher Collett ORCID: https://orcid.org/0000-0002-0102-3453 2007. An observational study of empirical antibiotics for adult women with uncomplicated UTI in general practice. Journal of Antimicrobial Chemotherapy 59 (6) , pp. 1200-1203. 10.1093/jac/dkm108

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Abstract

Objectives Women presenting in primary care with symptoms suggestive of uncomplicated urinary tract infection (UTI) are commonly managed without urine culture. We therefore do not know how successful general practitioners (GPs) are at targeting antibiotic treatment to women who would have had a microbiologically confirmed UTI, or at avoiding antibiotics in those who would have had a negative culture, had all patients with a suspected UTI been sampled. We therefore explored the association between antibiotic prescribing and urine culture results when culture was performed in all symptomatic patients. Methods GPs in nine general practices in South Wales were asked to submit urine specimens from all women consulting with clinically suspected, uncomplicated UTI. Patients were followed up 2 weeks later by questionnaire. Results and conclusions One hundred and thirteen adult women with a median age of 54 years were included and 61% received empirical antibiotics. There was very low agreement between the decision to prescribe empirically and subsequent culture result (Kappa = 0.04), with 60% of those prescribed empirical antibiotics subsequently found to have a negative culture, and 25% of those found to have a positive culture not prescribed empirical antibiotics. Current strategies to target empirical antibiotic prescribing in clinically suspected, uncomplicated UTI require review.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	urinary tract infections; cystitis; urine culture; empirical antibiotics
Publisher:	Oxford University Press
ISSN:	0305-7453
Last Modified:	25 Oct 2022 09:35
URI:	https://orca.cardiff.ac.uk/id/eprint/59240

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