All trans retinoic acid enhances human LAK activity

Fegan, C., Bailey-Wood, R., Coleman, Sharon Louise, Phillips, S. A., Neale, L., Hoy, T. and Whittaker, J. A. 1995. All trans retinoic acid enhances human LAK activity. European Journal of Haematology 54 (2) , pp. 95-100. 10.1111/j.1600-0609.1995.tb01774.x

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Abstract

All trans retinoic acid has various effects on normal and malignant cells. Lymphokine-activated killer (LAK) activity can be derived from T lymphocytes and natural killer cells. This study shows that all trans retinoic acid significantly enhances this activity by increasing production of tumour necrosis factor and gamma interferon, which results in enhanced expression of the p55 part of the interleukin 2 receptor. This effect is dependent on the concentration of all trans retinoic acid and the length of time of culture.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > R Medicine (General)
Uncontrolled Keywords:	interleukin 2; tumour-necrosis factor; gamma interferon; lymphokine-activated killer cells; all trans retinoic acid
Publisher:	Wiley-Blackwell
ISSN:	0902-4441
Last Modified:	19 Mar 2016 23:41
URI:	https://orca.cardiff.ac.uk/id/eprint/60591

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