Routledge, Philip Alexander and Hutchings, Alun 2013. Therapeutic drug monitoring (TDM). Wild, David, ed. The immunoassay handbook : Theory and Applications of Ligand Binding, ELISA and Related Techniques, Oxford: Elsevier, pp. 945-962. (10.1016/B978-0-08-097037-0.00076-2) |
Abstract
This chapter provides a review of the use of immunoassay in therapeutic drug monitoring. The immunoassay technology commonly used in this field is described (radioimmunoassay, enzyme-multiplied immunoassay technique, cloned enzyme donor immunoassay, enzyme-linked immunosorbent assay, homogeneous fluorescence enhancement and quenching assays, fluorescence polarization and microparticle enzyme immunoassay. Measurement of free drug concentration is reviewed and there is a section on practical aspects and assay interferences. The drugs are then reviewed in individual sections with these subsections: clinical applications, mode of administration, pharmacological effects, pharmacokinetics, therapeutic range, potentially toxic concentration, side effects and type of sample. The drugs described are: acecainide (n-acetylprocainamide), digoxin, digitoxin, procainamide, quinidine, theophylline, amikacin, gentamicin, tobramycin, vancomycin, carbamazepine, gabapentin, lamotrigine, levetiracetam, phenobarbital, phenytoin (diphenylhydantoin), primidone, topiramate, valproic acid, zonisamide, ciclosporin (cyclosporin), methotrexate, mycophenolic acid, sirolimus, tacrolimus, acetaminophen (paracetamol), and the tricyclic antidepressants amitriptyline, imipramine and desipramine.
Item Type: | Book Section |
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Date Type: | Publication |
Status: | Published |
Schools: | Medicine Pharmacy |
Subjects: | R Medicine > RS Pharmacy and materia medica |
Publisher: | Elsevier |
ISBN: | 9780080970370 |
Last Modified: | 05 Nov 2019 04:11 |
URI: | https://orca.cardiff.ac.uk/id/eprint/61009 |
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