Assaf, Yaniv, Alexander, Daniel C., Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049, Bizzi, Albero, Behrens, Tim E. J., Clark, Chris A., Cohen, Yoram, Dyrby, Tim B., Huppi, Petra S., Knoesche, Thomas R., LeBihan, Denis, Parker, Geoff J. M. and Poupon, Cyril 2013. The CONNECT project: Combining macro- and micro-structure. NeuroImage 80 , pp. 273-282. 10.1016/j.neuroimage.2013.05.055 |
Preview |
PDF
- Accepted Post-Print Version
Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
In recent years, diffusion MRI has become an extremely important tool for studying the morphology of living brain tissue, as it provides unique insights into both its macrostructure and microstructure. Recent applications of diffusion MRI aimed to characterize the structural connectome using tractography to infer connectivity between brain regions. In parallel to the development of tractography, additional diffusion MRI based frameworks (CHARMED, AxCaliber, ActiveAx) were developed enabling the extraction of a multitude of micro-structural parameters (axon diameter distribution, mean axonal diameter and axonal density). This unique insight into both tissue microstructure and connectivity has enormous potential value in understanding the structure and organization of the brain as well as providing unique insights to abnormalities that underpin disease states. The CONNECT (Consortium Of Neuroimagers for the Non-invasive Exploration of brain Connectivity and Tracts) project aimed to combine tractography and micro-structural measures of the living human brain in order to obtain a better estimate of the connectome, while also striving to extend validation of these measurements. This paper summarizes the project and describes the perspective of using micro-structural measures to study the connectome.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Cardiff University Brain Research Imaging Centre (CUBRIC) Neuroscience and Mental Health Research Institute (NMHRI) Psychology |
Subjects: | B Philosophy. Psychology. Religion > BF Psychology |
Publisher: | Elsevier |
ISSN: | 1053-8119 |
Date of First Compliant Deposit: | 14 December 2016 |
Date of Acceptance: | 8 May 2013 |
Last Modified: | 18 Nov 2024 00:00 |
URI: | https://orca.cardiff.ac.uk/id/eprint/61033 |
Citation Data
Cited 75 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |