A Gr receptor is required for response to the sugar rehalose in taste neurons of Drosophiila

Dahanukar, A., Foster, K., Van Der Goes Van Naters, Wynand ORCID: https://orcid.org/0000-0002-6808-0161 and Carlson, J. R. 2001. A Gr receptor is required for response to the sugar rehalose in taste neurons of Drosophiila. Nature Neuroscience 4 (12) , pp. 1182-1186. 10.1038/nn765

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Abstract

We recently identified from the Drosophila genome database a large family of G protein-coupled receptor genes, the Gr genes, and predicted that they encode taste receptors on the basis of their structure and specificity of expression. The expression of Gr genes in gustatory neurons has subsequently been confirmed and 56 family members have been reported. Here we provide functional evidence that one Gr gene, Gr5a, encodes a taste receptor required for response to the sugar trehalose. In two different mutants that carry deletions in Gr5a, electrophysiological and behavioral responses to trehalose were diminished but the response to sucrose was unaffected. Transgenic rescue experiments showed that Gr5a confers response to trehalose. The results correlate a particular taste ligand with a Gr receptor and indicate a role for G protein-mediated signaling in the transduction of sweet taste in Drosophila.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
ISSN:	1097-6256
Last Modified:	25 Oct 2022 10:06
URI:	https://orca.cardiff.ac.uk/id/eprint/61155

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