Cooper, Miriam  ORCID: https://orcid.org/0000-0002-4695-5481, Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X and Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049
2014.
White matter microstructure predicts autistic traits in attention-deficit/hyperactivity disorder.
Journal of Autism and Developmental Disorders
44
(11)
, pp. 2742-2754.
10.1007/s10803-014-2131-9
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Abstract
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Research Institutes & Centres > MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Research Institutes & Centres > Cardiff University Brain Research Imaging Centre (CUBRIC) Schools > Medicine Research Institutes & Centres > Neuroscience and Mental Health Research Institute (NMHII) Schools > Psychology |
| Subjects: | R Medicine > R Medicine (General) |
| Additional Information: | This paper has an Erratum notice: Cooper, M., Thapar, A. & Jones, D.K. Erratum to: White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder. J Autism Dev Disord 44, 2755 (2014). https://doi.org/10.1007/s10803-014-2162-2 |
| Publisher: | Springer Verlag |
| ISSN: | 0162-3257 |
| Funders: | Wellcome Trust |
| Related URLs: | |
| Date of First Compliant Deposit: | 30 March 2016 |
| Last Modified: | 05 Jun 2024 11:20 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/61271 |
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