Cooper, Miriam ![]() ![]() ![]() |
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Abstract
Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Cardiff University Brain Research Imaging Centre (CUBRIC) Medicine Neuroscience and Mental Health Research Institute (NMHRI) Psychology |
Subjects: | R Medicine > R Medicine (General) |
Publisher: | Springer Verlag |
ISSN: | 0162-3257 |
Funders: | Wellcome Trust |
Date of First Compliant Deposit: | 30 March 2016 |
Last Modified: | 12 May 2023 16:59 |
URI: | https://orca.cardiff.ac.uk/id/eprint/61271 |
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Cited 8 times in Scopus. View in Scopus. Powered By Scopus® Data
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