White matter microstructure predicts autistic traits in attention-deficit/hyperactivity disorder

Cooper, Miriam ORCID: https://orcid.org/0000-0002-4695-5481, Thapar, Anita ORCID: https://orcid.org/0000-0002-3689-737X and Jones, Derek K. ORCID: https://orcid.org/0000-0003-4409-8049 2014. White matter microstructure predicts autistic traits in attention-deficit/hyperactivity disorder. Journal of Autism and Developmental Disorders 44 (11) , pp. 2742-2754. 10.1007/s10803-014-2131-9

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Abstract

Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) Cardiff University Brain Research Imaging Centre (CUBRIC) Medicine Neuroscience and Mental Health Research Institute (NMHRI) Psychology
Subjects:	R Medicine > R Medicine (General)
Publisher:	Springer Verlag
ISSN:	0162-3257
Funders:	Wellcome Trust
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 May 2023 16:59
URI:	https://orca.cardiff.ac.uk/id/eprint/61271

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