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White matter microstructure predicts autistic traits in attention-deficit/hyperactivity disorder

Cooper, Miriam ORCID:, Thapar, Anita ORCID: and Jones, Derek K. ORCID: 2014. White matter microstructure predicts autistic traits in attention-deficit/hyperactivity disorder. Journal of Autism and Developmental Disorders 44 (11) , pp. 2742-2754. 10.1007/s10803-014-2131-9

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Traits of autism spectrum disorder (ASD) in children with attention-deficit/hyperactivity disorder (ADHD) have previously been found to index clinical severity. This study examined the association of ASD traits with diffusion parameters in adolescent males with ADHD (n = 17), and also compared WM microstructure relative to controls (n = 17). Significant associations (p < 0.05, corrected) were found between fractional anisotropy/radial diffusivity and ASD trait severity (positive and negative correlations respectively), mostly in the right posterior limb of the internal capsule/corticospinal tract, right cerebellar peduncle and the midbrain. No case–control differences were found for the diffusion parameters investigated. This is the first report of a WM microstructural signature of autistic traits in ADHD. Thus, even in the absence of full disorder, ASD traits may index a distinctive underlying neurobiology in ADHD.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Cardiff University Brain Research Imaging Centre (CUBRIC)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Additional Information: This paper has an Erratum notice: Cooper, M., Thapar, A. & Jones, D.K. Erratum to: White Matter Microstructure Predicts Autistic Traits in Attention-Deficit/Hyperactivity Disorder. J Autism Dev Disord 44, 2755 (2014).
Publisher: Springer Verlag
ISSN: 0162-3257
Funders: Wellcome Trust
Related URLs:
Date of First Compliant Deposit: 30 March 2016
Last Modified: 05 Jun 2024 11:20

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